ABSTRACT
OBJECTIVE: To study the chemical constituents from n-butanol part in Toddalia asiatica root bark. METHODS: A variety of chromatographic techniques were applied to extract, isolate and purify natural products from extract of Toddalia asiatica root bark, their structures were identified on the basis of spectral data. RESULTS: Thirteen compounds were isolated from n-butanol part in Toddalia asiatica root bark, there were seven coumarin compounds, including six furocoumarin compounds, identified as pimpinellin (1), bergapten (2), alloimperatorin (3), isopimpinellin (4), moellendorffiline (5), phellopterin (6), toddalolactone (7); four organic acid ester compounds identified as mono (2-ethylhexyl) terephthalate (8), ferulic acid methyl ester (9), 4-methoxycinnamic acid (10), methyl trans-4-hydroxycinnamate (11); one alkaloid identified as nitidine (12) and one flavonoid compound which was hesperidin (13). CONCLUSION: The compound 8 is isolated from the Rutaceae family for the first time, compound 3, 5, 9, 10, 11 are isolated from this plant for the first time.